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KMID : 1144120110010040213
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Biomedical Engineering Letters
2011 Volume.1 No. 4 p.213 ~ p.219
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Rheology of osteoarthritic synovial fluid mixed with viscosupplements: A pilot study
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Bhuanantanondh Petcharatana
Grecov Dana
Kwok Ezra
Guy Pierre
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Abstract
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Purpose: Osteoarthritis (OA) is a degenerative joint disease that is characterized by the breakdown of articular cartilage. Rheology of synovial fluid is of interest because of its significance in joint lubrication. However, there are still many questions related to synovial fluid rheology and its relation with OA. Although viscosupplementation has been used as a treatment for OA for many years, its clinical effect remains controversial. Therefore, the purpose of this study is to determine in vitro the effect of different viscosupplements on the rheological properties of synovial fluid.
Methods: A detailed rheological characterization of synovial fluid from 26 patients undergoing total knee arthroplasty (TKA) was performed. The rheological properties of the osteoarthritic synovial fluid added with viscosupplements were compared with those of the healthy human synovial fluid in order to assess the restorative effect on naturally occurring synovial fluid within the joint. Furthermore, the stability of rheological properties of synovial fluid mixed with viscosupplements in vitro over 8 weeks was analyzed.
Results: The addition of a cross-linked viscosupplement to OA synovial fluid was found to be more efficient than linear ones in improving the overall rheological properties of synovial fluid. The findings indicate that the rheological properties of SF mixed with VSs changed over 8 weeks.
Conclusions: The findings from this study will lead to a better understanding of the role of viscosupplements in joint lubrication and OA.
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KEYWORD
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Hyaluronic acid, Molecular weight, Viscoelasticity, Shear steady viscometry, Stability of rheological properties
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